Abnormal Flow of Sickled Cells Damages Blood Vessel Walls

Red blood cells in people with sickle cell disease (SCD) flow through blood vessels in a manner that damages the walls, which may explain blood vessel problems and increased inflammation in SCD, new research indicates. The study, “Flow-induced segregation and dynamics of red blood cells in sickle cell…

Computer Model Reveals Underlying Mechanism of Hemoglobin S Fibers in Sickle Cell Disease

Researchers at Brown University have developed computer models that recreate what happens with hemoglobin molecules inside red blood cells  affected by sickle cell disease. Their study, “Mesoscopic Adaptive Resolution Scheme toward Understanding of Interactions between Sickle Cell Fibers,” appeared in the Biophysical Journal. It describes a virtual model authors hope…