Fentanyl may be a feasible, safe, and effective option when administered intranasally (into the nose), to manage acute moderate to severe pain episodes in adults with sickle cell disease (SCD), a study in Canada reports. For faster and non-invasive pain relief, it has been widely used in children with…
The investigational gene-editing therapy OTQ923 resulted in normalization of the speed of blood flow in the brain of three adults with sickle cell disease (SCD), according to data from a Phase 1 clinical trial. Findings suggest the treatment could help lower the risk of stroke in patients. The…
Most people with sickle cell disease (SCD) seem to meet or exceed current physical activity recommendations for the general population, a recent study in Senegal shows. Notably, greater step counts and time spent in more intense activities were associated with lower pain frequency and intensity, as well as lower…
From illuminating public buildings in red to candlelight vigils and walks, supporters are gearing up to raise awareness and increase public knowledge about sickle cell disease (SCD) on June 19, World Sickle Cell Day. This year’s global theme is “Global Action, Local Impact: Empowering Communities for Effective Self-Advocacy.” SCD…
Meningitis — an inflammation of the protective membranes surrounding the brain and spinal cord — remains associated with a case-fatality rate of nearly 30% in children with sickle cell disease (SCD), according to the findings of a new two-decade study from France. This is despite vaccinations for SCD children…
Top-line data from the Phase 3 part of RISE UP, a clinical trial testing mitapivat in people with sickle cell disease (SCD), are expected by the end of the year, according to developer Agios Pharmaceuticals. If those results are positive and mitapivat wins regulatory approval for SCD, it…
The use of computed tomography pulmonary angiography (CTPA) to assess the presence of blood clots in lung blood vessels increased significantly in people with sickle cell disease (SCD) after 2020, a study in Bahrain shows. The study indicates that a third of patients underwent several scans, many of which…
More perceived social support from classmates is associated with less disease severity among children and adolescents with sickle cell anemia, the most common and often the most severe form of sickle cell disease (SCD), according to a new study from researchers in Nigeria. Social support from parents also was…
A toolkit may facilitate the active involvement of parents of young children with sickle cell disease (SCD) in shared decision-making regarding hydroxyurea treatment for their children, a study suggests. However, the odds of these young patients being offered and prescribed hydroxyurea were higher among those who received usual…
Hydroxyurea may effectively reduce the risk of stroke in children with sickle cell disease (SCD), a systematic review has found. “This review highlights the need for further research to understand the real-world feasibility and practical implications of hydroxyurea dosing strategies and to explore its long-term safety and efficacy…
Get regular updates to your inbox.