Posts by: Iqra Mumal

Researchers have pinpointed a specific genetic profile that could help identify sickle cell disease (SCD) patients who are at risk for developing acute chest syndrome (ACS), a common and ... Read more

March 20, 2018March 20, 2018

Researchers Report Great Success in Stemming Graft-Versus-Host Disease in SCD Patients

Researchers found that a new conditioning regimen for adult sickle cell disease (SCD) patients undergoing allogeneic peripheral blood stem cell transplantation (allo-PSCT) shows remarkable success in preventing the immune ... Read more

February 6, 2018

Two Types of CRISPR Gene Editing Could Be Useful in Treating Sickle Cell Anemia, Editas Reports

Two kinds of CRISPR gene editing therapies show promise as treatments for a number of blood diseases, including sickle cell anemia, Editas Medicine reports. Gene editing is one of a wave ... Read more

February 1, 2018

Hydroxyurea Treatment in Men with SCA Leads to Drop in Total Sperm Count, Study Shows

Researchers found that treatment with hydroxyurea at currently approved doses for sickle cell anemia leads to a significant drop in total sperm count in men. The study, “Adverse effect ... Read more

January 25, 2018

How a Man and Woman, Both with a Sickle Cell Anemia Mutation, Had a Healthy Child

A man and woman who are both carriers of the sickle cell anemia mutation can have a healthy child by fertilizing eggs in a lab, then deciding which of ... Read more

January 4, 2018January 4, 2018

Novartis Therapy Crizanlizumab Prolongs Time to First Sickle Cell Pain Crisis, Study Finds

Crizanlizumab (SEG101), manufactured by Switzerland’s Novartis, delays the time to first sickle cell pain crisis (SCPC) in adults with sickle cell disease, according to results from a subgroup analysis of the ... Read more

December 12, 2017

Intellia Uses Gene Editing to Replace Defective Blood Component in Sickle Cell Disease

Intellia Therapeutics has used gene editing to replace an oxygen-carrying component in blood that is defective in sickle cell disease. The work involved editing the BCL11A gene in a mouse ... Read more

November 16, 2017

Increase in a Type of Gut Bacteria Linked to More Pain in Patients with Sickle Cell Disease

Howard University researchers have discovered a link between increases in Veillonella gut bacteria and higher levels of pain in sickle cell disease patients. The team presented their findings at the American Physiological Society’s ... Read more

October 17, 2017October 17, 2017

Research into New Therapies for Sickle Cell Disease Gets Funding Boost

The Medical University of South Carolina (MUSC) was recently awarded a Doris Duke Charitable Foundation grant to develop a new gene-modifying therapy for the treatment of sickle cell disease. The project, ... Read more