Young people with sickle cell disease (SCD) who live in areas with more air pollution are more likely to be hospitalized due to acute chest syndrome (ACS), an SCD complication marked by symptoms that can include chest pain and difficulty breathing, a study found. “As ACS is a…
People with severe sickle cell disease (SCD) have reported significant improvements in their quality of life after receiving the approved gene-editing therapy Casgevy (exagamglogene autotemcel). That’s according to a new analysis of data from patients involved in a clinical trial that had tested the SCD treatment in individuals…
Correctsequence Therapeutics’ experimental gene-editing therapy CS-101 has been used to treat a person with sickle cell disease (SCD) for the first time. Prior to treatment with CS-101, the patient — a 21-year-old woman from Nigeria — had been experiencing frequent vaso-occlusive crises (VOCs), or painful episodes caused by…
People with sickle cell disease (SCD) may have a higher risk of developing blood cancer, but a lower risk of certain types of solid tumor malignancies, such as breast and prostate cancer, a systematic review study suggests. The study, “Risk of cancer in patients with thalassemia…
BEAM-101, a genetically modified cell therapy for sickle cell disease (SCD) that’s being tested in clinical trials, has been granted orphan drug status by the U.S. Food and Drug Administration (FDA). The FDA gives the designation to experimental therapies designed to treat conditions that affect fewer than 200,000 people…
An algorithm that grew out of a collaboration between different specialties at the Medical University of South Carolina (MUSC) may help reduce unnecessary hospital admissions for children with sickle cell disease (SCD), according to a new study. “This algorithm safely allows our care of these patients to align with…
Bluebird Bio and Xcellbio have entered into an agreement to support the commercialization of Lyfgenia (lovotibeglogene autotemcel), Bluebird’s gene therapy for sickle cell disease, incorporating Xcellbio technology into Bluebird’s potency assay with the aim of helping to ensure the therapy’s effectiveness. “We’re humbled to play a small part in…
This year, for the first time, two teenagers in Florence, South Carolina, are going to be able to go swimming on spring break without worrying about serious complications from sickle cell disease (SCD). Ashanti and Dontrell Pickens have long wanted to swim on their school holidays, but were not…
This month, the University of Tennessee Health Science Center College of Nursing is hosting a conference that aims to educate primary care doctors about sickle cell disease (SCD). The Sickle Cell Disease Comprehensive Management for Health Care Providers conference is being funded by a two-year, $364,502 grant from the…
Scientists have discovered more than a dozen genes that regulate the production of fetal hemoglobin in people of African descent, which may be potential treatment targets for sickle cell disease (SCD). Their findings were reported in the study, “FLT1 and other candidate fetal haemoglobin modifying loci…
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