Posts by: Joana Carvalho

News

Sevuparin, Modus Therapeutics‘ lead therapeutic candidate for managing painful vaso-occlusive crises (VOCs), failed to show clinically meaningful improvements in patients with sickle cell disease (SCD), Phase 2 clinical trial results ... Read more

May 2, 2019

Findings on Abnormal Hemoglobin Assembly Could Lead to Lower-Dose SCD Medications, Researchers Say

News

A study of sickle cell disease (SCD) at the molecular level found abnormal hemoglobin molecules assemble much faster and less efficiently than previously thought — findings that could lead ... Read more

April 11, 2019April 11, 2019

Abnormal Red Blood Cells’ Shape Affect Blood Clot Formation, Study Shows

News

Abnormal sickle-shaped red blood cells characteristic of sickle cell disease (SCD) change the structure and dynamics of blood clots’ formations in veins, a study in mice and human blood ... Read more

March 28, 2019March 28, 2019

Alterations in Blood Vessels of the Lungs Should be Monitored in SCD Patients, Study Says

News

Alterations in the lungs’ network of blood vessels, caused by sickle cell disease (SCD), reflect disease burden and should be carefully monitored over time, a recent study says. The ... Read more

March 19, 2019March 19, 2019

Oral Morphine is a Viable Treatment Option for SCD Patients Experiencing VOCs, Study Says

News

Oral morphine treatment is a valid therapy option for patients with sickle cell disease (SCD) who are undergoing a vaso-occlusive crisis (VOC), researchers suggest. It was found to significantly reduce ... Read more

March 12, 2019March 12, 2019

Weight-loss Surgery May Help Reduce VOCs in Morbidly Obese SCD Patients

News

Bariatric surgery may help reduce the rates of vaso-occlusive crises (VOCs) in morbidly obese patients with sickle cell disease (SCD) without increasing the risk of mortality or other adverse events, a ... Read more

March 5, 2019March 5, 2019

Differences in Brain Oxygen Supply May Explain Silent Strokes in SCD Patients

News

Brain oxygen supply is different in different regions of the brain of sickle cell disease (SCD) patients who are affected by anemia, which may explain the incidence of silent strokes, ... Read more

February 12, 2019February 19, 2019

ATS Releases Guidelines for Home Oxygen Therapy in Children with Sickle Cell Disease

News

The American Thoracic Society (ATS) released a set of new guidelines for home oxygen therapy for children with chronic health conditions that cause a reduction in blood oxygen levels, ... Read more

January 10, 2019January 11, 2019

Crizanlizumab Designated FDA Breakthrough Therapy for Potential in Vaso-occlusive Crisis Prevention

News

Crizanlizumab (SEG101), Novartis‘ investigational compound for sickle cell disease (SCD), received breakthrough therapy designation from the U.S. Food and Drug Administration for its potential to prevent vaso-occlusive crises (VOCs). The FDA ... Read more

September 4, 2018September 4, 2018

Altemia Shows Promising Results in Phase 2 Trial for SCD Children

News

Sancilio Pharmaceuticals‘ investigational oral compound Altemia (SC411) shows promising results in treating children with sickle cell disease (SCD), a Phase 2 clinical trial reveals. The study, “Double-blind, randomized, multicenter ... Read more