Posts by: Jose Marques Lopes, PhD

News

Children and adolescents with sickle cell anemia (SCA) showed low adherence to treatment with hydroxyurea, according to a multi-state study in the U.S. The research, “Hydroxyurea use among children ... Read more

January 3, 2019January 3, 2019

Hospitals See No Link Between US Opioid Crisis and Patients’ Use of Treatment, Study Reports

News

The U.S. opioid epidemic is not linked to higher in-hospital mortality in patients with sickle cell disease (SCD), according to a national study. The study came about due to ... Read more

September 20, 2018September 20, 2018

IP-10 Could Be Biomarker of Inflammation in Pregnant Sickle Cell Patients, Study Reports

News

The blood level of a small protein called IP-10 could be a way to determine inflammation in pregnant women with sickle cell disease (SCD), according to new research in potential ... Read more

May 8, 2018May 8, 2018

Stem Cells from Half-Matched Donors in New Approach Reported to Cure 7 Sickle Cell Patients

News

Under a new treatment protocol, seven adults with sickle cell anemia were treated — and reportedly cured — using stem cells from donors previously seen as incompatible. The study ... Read more

April 24, 2018April 24, 2018

In-person Caregiver Education Increases Sickle Cell Trait Knowledge, Study Reports

News

In-person education of caregivers increases their knowledge of sickle cell trait (SCT), according to researchers. But new strategies are needed to make sure caregivers don’t forget what they learned. The ... Read more

March 13, 2018March 13, 2018

CRISPR/Cas9 Gene Editing Shows Potential to Treat Sickle Cell Disease, Study Reports

News

A gene editing technology called CRISPR/Cas9 repaired 20 to 40 percent of stem and progenitor cells obtained from sickle cell disease patients, scientists report, suggesting such an approach might ... Read more

March 6, 2018

Phase 1 Clinical Trial for Novel Sickle Cell Transplant Procedure Receives $5.74 Million

News

An upcoming Phase 1 clinical trial was recently awarded $5.74 million to evaluate an innovative blood stem cell transplant procedure for adults with severe sickle cell disease (SCD). The California ... Read more

January 16, 2018

FDA Grants Breakthrough Therapy Designation to Voxelotor

News

Voxelotor, a potential treatment for sickle cell anemia (SCA), has been given breakthrough therapy designation (BTD), Global Blood Therapeutics (GBT) recently announced. Voxelotor (previously called GBT440) is a potential ... Read more

September 7, 2017September 7, 2017

CSL Behring’s Acquisition of Calimmune May Spur New Therapies to Treat Sickle Cell Disease

News

New therapies to treat sickle cell disease (SCD) may receive a boost after CSL Behring‘s recent $91 million acquisition of Calimmune. CSL Behring will now develop Calimmune’s pre-clinical product, CAL-H — ... Read more

June 6, 2017June 6, 2017

New Pre-transplant Treatment Regimen Improves Survival of Kids with Sickle Cell Disease, Trial Shows

News

A new pre-transplant conditioning regimen remarkably improves rejection rates and survival in children with sickle cell disease (SCD), according to the results of Phase 1/2 trial (NCT00920972). The study, ... Read more