News

Hydroxyurea may help ease sleep issues in children: Study

Hydroxyurea, an approved medication to reduce the frequency of pain crises associated with sickle cell disease (SCD), may ease sleep-disordered breathing in children, perhaps by reducing inflammation, according to a study conducted at St. Jude Children’s Research Hospital, in Memphis. “Hydroxyurea therapy was associated with improved breathing…

Proof-of-concept study to test curcumin gel VAS-101 in SCD

Vascarta is launching a proof-of-concept Phase 1 clinical study to test its topical curcumin gel VAS-101 — which uses a component of turmeric — in people with sickle cell disease (SCD). The experimental therapy, also known as Vascepto, is designed to be applied onto the skin. It contains curcumin,…

Inflammation during menstrual cycle may trigger VOEs: Study

Women with sickle cell disease (SCD) have markedly elevated levels of C-reactive protein (CRP), a marker of body-wide inflammation, during the first half of their menstrual cycles, and these variations may contribute to recurrent patterns of vaso-occlusive events (VOEs), complications resulting from blood vessel obstruction that include painful…

New model developed to track inflammation-driven blood clots

Researchers have developed a modelling system of tiny blood vessels to track inflammation-driven blood clot formation that can cause complications in sickle cell disease (SCD) and other conditions. “One of the biggest things about being able to create [blood clots] under inflammatory conditions is that we are now able…

Companies team up to support sickle cell gene therapy Lyfgenia

Bluebird Bio and Xcellbio have entered into an agreement to support the commercialization of Lyfgenia (lovotibeglogene autotemcel), Bluebird’s gene therapy for sickle cell disease, incorporating Xcellbio technology into Bluebird’s potency assay with the aim of helping to ensure the therapy’s effectiveness. “We’re humbled to play a small part in…