Scientists have discovered more than a dozen genes that regulate the production of fetal hemoglobin in people of African descent, which may be potential treatment targets for sickle cell disease (SCD). Their findings were reported in the study, “FLT1 and other candidate fetal haemoglobin modifying loci…
People with sickle cell disease (SCD) who are hospitalized for opioid overdose have fewer serious complications than those without the condition, but face longer hospital stays, higher costs, and unique healthcare challenges that require specialized care, a study found. “A multidisciplinary approach to pain management, tailored to individual patient…
Zynext Ventures is investing in Illexcor Therapeutics to advance the clinical development of ILX002, its lead, novel oral candidate therapy for sickle cell disease (SCD), the companies announced. The financial details of the investment by Zynext Ventures, the venture capital arm of Zydus Lifesciences, were not disclosed.
Hydroxyurea may effectively reduce the risk of stroke in children with sickle cell disease (SCD), a systematic review has found. “This review highlights the need for further research to understand the real-world feasibility and practical implications of hydroxyurea dosing strategies and to explore its long-term safety and efficacy…
A scientist at Florida Atlantic University, Sarah E. Du, has been named a senior member of the U.S. National Academy of Inventors in recognition of her significant contributions to innovation and invention, including her work on diagnostic and monitoring tools for sickle cell disease (SCD). The academy’s Senior Members…
Despite advancements in medical care, pregnant women with sickle cell disease (SCD) are at a higher risk of complications and require close monitoring, a nationwide French study has found. SCD is associated with a significantly higher likelihood of maternal and fetal complications, preterm birth, and caesarean sections (C-sections), data…
Undergoing a bone marrow transplant during adolescence may reduce the risk of stroke in people with sickle cell disease (SCD), while waiting until adulthood is unlikely to mitigate this risk, a mouse study suggests. “We saw that if you wait until after the vasculature is damaged to do this…
Most people with sickle cell disease (SCD) who received a new type of stem cell transplant in a clinical trial were free of disease-related clinical events after two years, according to a study. The scientists said the findings demonstrate that the approach, which uses a lower-intensity conditioning regimen…
The incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease (SCD) is elevated during January to March, a large nationwide, retrospective study in the U.S. suggests. The findings reinforce the need for “recommendations for patients with SCD to take appropriate precautions in cold weather,”…
Sickle cell disease (SCD) is associated with enhanced immune B-cell responses and the production of self-reactive antibodies that target and destroy red blood cells, according to data from a mouse model of the disease and patient samples. These changes in immune responses were regulated by type-1 interferons (IFN-1), an…
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