A recently published study in the Journal of Clinical Investigation identified an association between worsening intravascular hemolysis (rupture or destruction of red blood cells) and the rapid clinical deterioration seen during adult transition in Sickle cell disease (SCD). The study, “Nonhematopoietic Nrf2 dominantly…
Sickle cell anemia (SCA), one of the most common hemoglobinopathies, is caused by a mutation in the β-globin gene. In a new research study, the hemorheological and hematological parameters in men suffering from SCA and priapism — a persistent and potentially painful state of penile erection — were investigated.
A study performed by researchers at Baskent University, in Ankara, Turkey, found that mutations in certain genes play a role in the deposition of iron in the liver of patients with sickle cell (SC) disease. Findings, presented in the study “Effect of Hereditary Hemochromatosis Gene (HFE)…
Acetylon Pharmaceuticals recently published the outcomes of its preclinical data concerning the mechanism of action of its selective inhibition based treatment of sickle cell (SC) disease/beta-thalassemia (BT). These findings, “Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2,” were published in…
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