The U.S. Food and Drug Administration (FDA) has placed a clinical hold on FTX-6058, an experimental therapy that Fulcrum Therapeutics is developing to treat sickle cell disease (SCD). Fulcrum announced it would be stopping dosing in an ongoing Phase 1b clinical trial (NCT05169580) that’s testing different…
News
Jasper Therapeutics’ investigational conditioning therapy briquilimab safely improved the success of stem cell transplants for three people with sickle cell disease (SCD), early Phase 1/2 trial data suggest. Stem cell transplant success was observed in all three patients treated with briquilimab, plus a less-aggressive non-myeloablative conditioning regimen,…
Treatment with hydroxyurea — approved to help reduce pain crises and the need for blood transfusions in sickle cell disease (SCD) — is associated with a higher incidence of spleen removal surgery among children with SCD, according to a recent study. The findings also indicated that SCD children…
Black women in California with sickle cell disease (SCD) have worse pregnancy outcomes than do Black women in the state who don’t have the inherited blood disorder, a new study reported. For pregnant Black women with SCD, the rates of both stillbirth and pregnancy-related complications are higher, the study…
Louisiana State University’s (LSU) Reilly Center for Media & Public Affairs will kick off season six of its Racism: Dismantling the System series on Feb. 15 with a free Zoom presentation on healthcare and people of color. The 3:30 p.m. CST event, presented in partnership with the Sickle Cell Association…
The American Red Cross Central Appalachian Region received $25,000 from the FirstEnergy Foundation on behalf of efforts to support people with sickle cell disease (SCD) and increase the number of Black people who donate blood. The American Red Cross Sickle Cell Initiative aims to improve the quality of…
The risk of pregnancy-related death is about 26 times higher among people with sickle cell disease (SCD) in the U.S. compared with the national average, a recent study reported. The rate of pregnancy-related complications among SCD patients has not improved in recent decades, the results indicate. “People with sickle…
A 16-year-old boy with sickle cell disease (SCD) was diagnosed with autosomal dominant polycystic kidney disease (ADPKD), an inherited condition that causes fluid-filled cysts to form in the kidneys, a case study reports The report, “Dual diagnosis of autosomal dominant polycystic kidney disease and sickle cell disease in…
Treatment with Adakveo (crizanlizumab) did not reduce the yearly occurrence of painful vaso-occlusive crises (VOCs) leading to a medical visit, as compared with a placebo, in people with sickle cell disease (SCD), according to preliminary data from an ongoing Phase 3 trial. The study, called STAND (NCT03814746), is…
Good oral health is essential in people with sickle cell anemia (SCA), according to a new study from Saudi Arabia that found that several disease-causing bacteria species — including Enterobacteriaceae — were significantly more abundant in a group of patients with poorer dental health than…
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