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Hydroxyurea Therapy Use in Children with Sickle Cell Anemia in New York Explored in Study

Researchers investigated the use of hydroxyurea, a drug approved to treat sickle cell anemia in adults, in young children in New York State who are receiving this treatment. The findings reveal that pediatric use of hydroxyurea is widespread and increasing, but that incomplete adherence may limit the treatment’s full disease-modifying effects. The study,…

Process for Improving Risk Assessment of Stroke in Sickle Cell Anemia Kids Developed by Researchers

Researchers developed a project using what are termed “quality improvement methods” to increase the number of sickle cell anemia (SCA) babies and toddlers between the ages of 24-27 months who undergo transcranial Doppler ultrasonography (TCD) to detect the risk of stroke. The findings show the intervention resulted in significantly improved TCD…

US-based Biopharma Presents Positive Data on Potential Sickle Cell Therapy at European Hematology Congress

Global Blood Therapeutics, a biopharma developing novel therapeutics for the treatment of blood-based disorders, recently announced new results from its ongoing Phase 1/2 study of GBT440-001 in sickle cell disease (SCD). The data, presented at the European Hematology Association’s 21st Congress in Copenhagen, further supports the company’s plans to develop GBT440 as a…

Total Immature Red Blood Cell Count May Be Significant in Sickle Cell Anemia and Important Therapeutic Target

Researchers investigated how the levels of reticulocytosis, the increase of circulating immature red blood cells, correlated with increased hospitalizations and cerebrovascular pathologies in pediatric patients with sickle cell anemia (SCA) receiving chronic transfusion therapy (CTT). According to the findings, in this group of children with SCA, cerebrovascular pathology at initiation…

Renal Papillary Necrosis in Sickle Cell Patients Studied in Nigeria

Researchers investigated renal papillary necrosis (RPN), a chronic complication of sickle cell anemia, and found low incidence in South-Eastern Nigerian sickle cell anemia patient cohort, but higher association rates with female patients. The study, “Prevalence and associations of symptomatic renal papillary necrosis in sickle cell anemia patients in South-Eastern Nigeria,” was…